Development of novel triazolo-thiadiazoles from heterogeneous ``green'' catalysis as protein tyrosine phosphatase 1b inhibitors

Baburajeev, C. P. and Mohan, C. D. and Ananda, H. and Rangappa, S. and Fuchs, J. E. and Jagadish, S. and Siveen, K. S. and Chinnathambi, A. and Alharbi, S. A. and Zayed, M. E. and Zhang, J. and Li, F. and Sethi, G. and Girish, K. S. and Bender, A. and Basappa and Rangappa, K. S. (2015) Development of novel triazolo-thiadiazoles from heterogeneous ``green'' catalysis as protein tyrosine phosphatase 1b inhibitors. SCIENTIFIC REPORTS, 5. ISSN 2045-2322

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Official URL: http://doi.org/10.1038/srep14195

Abstract

Condensed-bicyclic triazolo-thiadiazoles were synthesized via an efficient ``green'' catalyst strategy and identified as effective inhibitors of PTP1B in vitro. The lead compound, 6-(2-benzylphenyl)-3-phenyl-1,2,4] triazolo3]1,3,4] thiadiazole (BPTT) was most effective against human hepatoma cells, inhibits cell invasion, and decreases neovasculature in HUVEC and also tumor volume in EAT mouse models. This report describes an experimentally unidentified class of condensed-bicyclic triazolothiadiazoles targeting PTP1B and its analogs could be the therapeutic drug-seeds.

Item Type: Article
Subjects: C Chemical Science > Biochemistry
C Chemical Science > Chemistry
Divisions: Department of > Biochemistry
Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 30 May 2019 10:33
Last Modified: 30 May 2019 10:34
URI: http://eprints.uni-mysore.ac.in/id/eprint/699

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