Ethyl 2-(4-fluorobenzylidene)-3-oxobutanoate: Synthesis, crystal structure and antimicrobial activities

Dileep Kumar, A. and Karthik Kumara and Lokanath, N. K. and Ajay Kumar, K. and Prabhuswamy, M. (2016) Ethyl 2-(4-fluorobenzylidene)-3-oxobutanoate: Synthesis, crystal structure and antimicrobial activities. Chemical Data Collections, 5-6. 68 - 78.

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Official URL: https://doi.org/10.1016/j.cdc.2016.11.003

Abstract

Ethyl 2-(4-fluorobenzylidene)-3-oxobutanoate was synthesized by Knoevenagel condensation reaction of 4-fluorobenzaldehyde and ethyl acetoacetate in the presence of catalytic amount of piperidine and trifluoroacetic acid in benzene under reflux conditions. The structure of the synthesized molecule was obtained by spectral studies and was confirmed by X-ray diffraction studies. The title compound crystallizes in the monoclinic crystal system under the space group P21/n. The structure adopts a Z conformation about the CC bond. The synthesized new molecule was evaluated in vitro for its antifungal and antimicrobial susceptibilities.

Item Type: Article
Uncontrolled Keywords: Antimicrobial, Packing, Single crystal, Spectral studies, X-ray diffraction
Subjects: D Physical Science > Physics
Divisions: Department of > Physics
Depositing User: manjula User
Date Deposited: 30 May 2019 10:23
Last Modified: 18 Sep 2019 11:21
URI: http://eprints.uni-mysore.ac.in/id/eprint/696

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