Microwave-assisted synthesis of n-alkylated bibenzoimidazolyl derivatives: antimicrobial studies

Nanjunda Swamy, S. and Kavitha, C. V. and Priya, B. S. and Gaonkar, S. L. and Tejesvi, M. V. and Rangappa, K. S. (2009) Microwave-assisted synthesis of n-alkylated bibenzoimidazolyl derivatives: antimicrobial studies. Letters in Drug Design & Discovery, 6 (5). pp. 380-386. ISSN 1875-628X

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Official URL: http://doi.org/10.2174/1570180810906050380

Abstract

The purpose of this study was to evaluate the efficacy of newly synthesized bibenzoimidazolyl derivatives 2(a-i) as antimicrobials. These molecules are obtained by the reaction of different pharmaceutically important bioactive aralkyl halides with 1, 7'-dimethyl-2'-propyl-1H, 3'H-2,5']bibenzoimidazole in presence of powdered potassium carbonate in DMF solvent under both conventional and microwave methods. The microwave method offers the products 2(a-i) in higher yields compared to conventional method. All the synthesized compounds were characterized by IR, H-1 NMR and elemental analysis and evaluated their efficacy as antimicrobials. We observed the significant differences between the antimicrobial activities of the newly synthesized compounds based on their various substituents present at N1 position. Compounds 2h, 2a, 2c, 2e and 2f showed potent antimicrobial activity compared to standard drugs.

Item Type: Article
Uncontrolled Keywords: Bibenzoimidazole; N-alkylation; Microwave; Antimicrobials
Subjects: B Life Science > Biotechnology
C Chemical Science > Chemistry
Divisions: Department of > Biotechnology
Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 23 Aug 2019 06:14
Last Modified: 23 Aug 2019 06:14
URI: http://eprints.uni-mysore.ac.in/id/eprint/6951

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