Synthesis and crystal structure studies of (2RS)-3-[(2RS)-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]-2-(pyridin-3-yl)thiazolidin-4-one

Kavitha, C. V. and Basappa and Mantelingu, K. and Doreswamny, S. I. and Shashidhara Prasad, J. and Rangappa, K. S. (2006) Synthesis and crystal structure studies of (2RS)-3-[(2RS)-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]-2-(pyridin-3-yl)thiazolidin-4-one. Journal of Chemical Research (5). pp. 312-314.

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The compound (2RS)-3-[(2RS)-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]-2-(pyridin-3-yl)-thiazolidin-4-one 4 was synthesised via one-pot three-component system in three different methods, such as conventional (DCC), MW irradiation with solvent and MW irradiation without solvent methods. Among them, MW irradiation without solvent has the advantage of short time with high yield and environmentally benign. The synthesised compound was characterised by spectroscopic technique and finally confirmed by X-ray diffraction. The compound crystallises in the triclinic crystal system with Z= 2 in the space group Pi. The cell parametres are a = 10.317(9) angstrom, b=10.280(1) angstrom, c=11.408(6) angstrom, alpha = 73.824(6)degrees beta = 70.122(5)degrees gamma = 70.293(3)degrees and R-1 = 0.0527 for 10124 reflections [l>2 sigma(l)] The cyclohexane ring of the molecule is in chair conformation. The molecule exhibits intermolecular hydrogen bonds of type N-H...O and C-H...O.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: LA manjunath user
Date Deposited: 23 Aug 2019 05:29
Last Modified: 22 Nov 2022 09:30

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