Octacosanol isolated from tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-<kappa>B and its DNA binding activity

Thippeswamy, G. and Sheela, M. L. and Bharathi Salimath, P. (2008) Octacosanol isolated from tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-<kappa>B and its DNA binding activity. European Journal of Pharmacology, 588 (2). 141 - 150. ISSN 1879-0712

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Official URL: https://doi.org/10.1016/j.ejphar.2008.04.027

Abstract

Octacosanol is a long-chain aliphatic alcohol, which is the main component of policosanol used as a normolipidemic agent. It is known that angiogenesis is involved in tumor growth and metastasis. The present study identified octacosanol isolated from the plant Tinospora cordifolia as a new antiangiogenic compound with inhibitory effects on in vivo angiogenesis assays. Our results showed that octacosanol (i) inhibits proliferation of endothelial cells and Ehrlich ascites tumor cells, (ii) inhibits neovascularization induced by angiogenic factors in chick chorioallantoic membrane and rat cornea in vivo angiogenesis assays, (iii) inhibits secretion of ascites fluid in the growing tumor cells in vivo. Concerning the mechanism of action, octacosanol inhibited secretion of vascular endothelial growth factor into ascites fluid by the tumor cells. At the molecular level octacosanol markedly inhibits activity of matrix metalloproteinases (MMPs) and translocation of transcription factor nuclear factor-<kappa>B to nucleus. The mechanism of inhibition of angiogenesis by octacosanol reflects on its effect on tumor angiogenesis and metastasis.

Item Type: Article
Uncontrolled Keywords: Angiogenesis, Octacosanol, Ascites tumor, VEGF (vascular endothelial growth factor), NF-<kappa>B (nuclear factor-<kappa>B)
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: manjula User
Date Deposited: 20 Aug 2019 10:35
Last Modified: 20 Aug 2019 10:35
URI: http://eprints.uni-mysore.ac.in/id/eprint/6826

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