Moringa oleifera leaves as an inhibitor of human platelet aggregation

Arabshahi-Delouee, Saeedeh and Aalami, Mehran and Urooj, Asna and Krishnakantha, T. P. (2009) Moringa oleifera leaves as an inhibitor of human platelet aggregation. PHARMACEUTICAL BIOLOGY, 47 (8). pp. 734-739. ISSN 1744-5116

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Moringa oleifera L. (Moringaceae) leaves were examined for their effect on human platelet aggregation in vitro. The aqueous extract of Moringa oleifera leaves significantly (p <= 0.05) inhibited platelet aggregation induced by agonists such as adenosine diphosphate, collagen, and epinephrine. The degree of inhibitory activity varied depending on the agonist used, concentration of extract and duration of incubating the extract with platelets. Heat treatment reduced the inhibitory activity of extract against platelet aggregation. In addition, the extracts significantly (p <= 0.05) decreased the amount of malonaldehyde formed in agonist challenged platelets. This study is the first report on the effect of aqueous extract of Moringa oleifera leaves against human platelet aggregation. Overall, Moringa oleifera leaves have potential to protect platelets against aggregation.

Item Type: Article
Uncontrolled Keywords: Moringa oleifera; inhibitory activity; platelet aggregation
Subjects: B Life Science > Food Science and Nutrition
Divisions: Department of > Food Science and Nutrition
Depositing User: Shrirekha N
Date Deposited: 20 Aug 2019 09:38
Last Modified: 20 Aug 2019 09:38

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