Synthesis, characterization, and biological study of phenylalanine amide derivatives

Mahesh Bhat and Belagali, S. L. and Rajesh Shastry, P. and Ravishankar Rai, V. (2016) Synthesis, characterization, and biological study of phenylalanine amide derivatives. Monatsh Chem, 147 (11). pp. 2001-2008. ISSN 1434-4475

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Official URL: https://doi.org/10.1007/s00706-016-1700-3

Abstract

In the present study, a series of amide derivatives of 4-nitro-l-phenylalanine were synthesized with good yield from 4-nitro-l-phenylalanine and substituted anilines using propylphosphonic anhydride (T3P®) as coupling reagent and were characterized through the IR, LC–MS, 1H and 13C NMR spectral studies. The isolated products were screened for antimicrobial and antioxidant activities. Some of the compounds showed Microsporum gypsuem activity or were active against Candida albicans, also a few of compounds showed antibacterial activities. The resultant compounds screened for anti-oxidant activity, which showed good activity for DPPH scavenging and ABTS assay methods and others had moderately activity. Some amide compounds act as metal chelating ligands with Fe2+ ions.

Item Type: Article
Subjects: B Life Science > Environmental Science
B Life Science > Microbiology
Divisions: Department of > Microbiology
Depositing User: manjula User
Date Deposited: 30 May 2019 09:37
Last Modified: 30 May 2019 09:37
URI: http://eprints.uni-mysore.ac.in/id/eprint/679

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