An accessible route for the synthesis of novel lignan derivatives and their biological evaluation

Raghavendra, K. R. and Renuka, N. and Ajay Kumar, K. and Sheena, S. (2017) An accessible route for the synthesis of novel lignan derivatives and their biological evaluation. Pharmaceutical Chemistry Journal, 51 (8). pp. 661-669. ISSN 1573-9031

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Official URL: https://doi.org/10.1007/s11094-017-1671-7

Abstract

2-(Aryl(thiophen-2-yl)methyl)succinic acids (4a — 4d), 3-(aryl(thiophen-2-yl)methyl)dihydrofuran-2,5-diones (5a — 5d), 7-aryl-4-oxo-4,5,6,7-tetrahydrobenzobthiophene-6-carboxylic acids (6a -- 6d), and ethyl 7-aryl-4-oxo-4,5,6,7-tetrahydrobenzobthiophene-6-carboxylates (7a -- 7d) were synthesized via Stobbe condensation of aryl(thiophen-2-yl)methanones and diethyl succinate. The newly synthesized compounds (5a -- 5d, 6a -- 6d, and 7a - 7d) were screened in vitro for their antimicrobial and antioxidant properties. Compounds 5b, 6d, and 7d exhibited promising antifungal and antibacterial activity against various microorganisms tested. Compounds 7d and 7b showed remarkable DPPH radical scavenging abilities.

Item Type: Article
Uncontrolled Keywords: Antimicrobial Activity; Antioxidant Activity; Dpph; Lignans; MIC; antimicrobial activity, antioxidant activity, DPPH lignans, Stobbe condensation
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 30 May 2019 09:17
Last Modified: 30 May 2019 09:17
URI: http://eprints.uni-mysore.ac.in/id/eprint/678

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