Oxalylhydrazide and Malonohydrazide as building block for the synthesis of new substituted Pyrazoles with antioxidant activities

Rai, K. M. Lokanatha and Musad, Ebraheem Abdu (2012) Oxalylhydrazide and Malonohydrazide as building block for the synthesis of new substituted Pyrazoles with antioxidant activities. Rasayan Journal of Chemistry, 5 (3). pp. 376-390. ISSN 0976-0083

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Abstract

Four series of pyrazole derivatives (2a-j), (3a-j), (4a-j), (6a-j) and (7a-j) were synthesized. The first series of pyrazole derivatives (2a-j) were synthesized by the cyclocondensation reaction of oxalyldihydrazide 1 with various numbers of ß-diketones in molecular ratio 1:2 respectively. The second and third series of pyrazole derivatives (3aj) and (4a-j) were synthesized via cyclocondensation reaction of corresponding pyrazole derivative (2a-j) with thiourea and urea. While the series of pyrazoles (6a-j) were synthesized via cyclocondensation reaction of malonodihydrazide 5 with the same ß-diketones under identical molecular ratio (1:2). The series of tripyrazoles compounds (7a-j) were synthesized by cyclocondensation reaction of the hydrazine hydrate with corresponding pyrazole derivatives (6a-j) in molecular ratio 1:1. Compounds (6h), (2h) and (7h) showed higher antioxidant activity at 10µg/ml concentration compared to standard anti-oxidant. On the other hand compounds (6h), (6g) and (2h) at 40µg/ml concentration showed maximum anti-lipid peroxidation comparable to vitamin E. Structure of newly synthesized compounds were confirmed by elemental analysis and spectral IR, 1HNMR, 13CNMR data. The title compounds represent a novel class of antioxidant agents.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 19 Aug 2019 09:50
Last Modified: 13 Jan 2023 11:21
URI: http://eprints.uni-mysore.ac.in/id/eprint/6760

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