Therapeutic potential of probiotic lactobacillus plantarum MYS94 against campylobacter jejuni

Poornachandra Rao, K. and Hemanth Kumar, N. K. and Sreenivasa, M. Y. (2016) Therapeutic potential of probiotic lactobacillus plantarum MYS94 against campylobacter jejuni. International Journal of Current Microbiology and Applied Sciences (IJCMAS), 5 (12). pp. 869-883. ISSN 2319-7706

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Official URL: http://dx.doi.org/10.20546/ijcmas.2016.512.095

Abstract

Campylobacter jejuni is one of the most common intestinal pathogen causes of human gastroenterocolitis thereby leading to diarrhea and other serious post-infectious complications. Controlling the C. jejuni infection is critical for reducing campylobacteriosis for a healthy gut. In the current study, Lactobacillus plantarum MYS94 was isolated from traditional fermented wine and characterized for its probiotics properties and therapeutic potential against C. jejuni.The probiotic attributes revealed that, the strain could resist the gut pH, bile salt tolerance, adherence ability to chicken crop epithelial cells, sensitivity to penicillin, amoxicillin, bacitracin and erythromycin, further the strain also exhibited inhibitory potential against common food pathogens. The neutralized cell-free supernatant of Lp MYS94 exhibited 62.04% inhibition of Pseudomonas aeruginosa MTCC 7903 biofilm. The study also evaluated the cholesterol-lowering property of the Lp MYS94 using hen egg yolk as the cholesterol source. The cholesterol in hen egg yolk was assimilated by 62.18% and 31.42% by Lp MYS94and its CFS respectively. In addition, Lp MYS94-CFS tested against C. jejuni by well diffusion and time kill assay revealed a significant effect on C. jejuni with strong inhibitory activity. Collectively, the results suggests that L. plantarum MYS94 could be useful as potential probiotic strain suppressing C. jejuni.

Item Type: Article
Subjects: B Life Science > Microbiology
Divisions: Department of > Botany
Department of > Microbiology
Depositing User: manjula User
Date Deposited: 30 May 2019 07:45
Last Modified: 30 May 2019 07:45
URI: http://eprints.uni-mysore.ac.in/id/eprint/676

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