A Facile Route for the Synthesis of Ethyl N-aryl-2,6-dioxo-piperid-3-ene-4-carboxylates and their Biological Activity

Ajay Kumar, K. and Lokanatha Rai, K. M. and Vasanth Kumar, G. and Mylarappa, B. N. (2012) A Facile Route for the Synthesis of Ethyl N-aryl-2,6-dioxo-piperid-3-ene-4-carboxylates and their Biological Activity. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (S4). pp. 564-568. ISSN 0975-1491

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Abstract

Cyclopropyl derivatives and piperidinediones have known to exhibit enormous amount of biological activities. In the present study the synthesis of biologically potent ethyl N-aryl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylates (2), N-aryl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acids (3) and ethyl 2,6-dioxo-N-aryl-piperid-3-ene-4-carboxylates (4) were described. The compounds (2, 4) were evaluated in vitro for their antibacterial, antifungal, antioxidant and reducing ability. The findings revealed that compounds (2) may be used as control measures against different bacterium and fungi, and (4) can be used as reference standard for antioxidant activities.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 19 Aug 2019 06:09
Last Modified: 19 Aug 2019 06:09
URI: http://eprints.uni-mysore.ac.in/id/eprint/6743

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