Bioactive potential of herbaceous phyllanthus species

Sampath Kumara, K. K. and Chethan, J. and Manasa, N. and Ashadevi, J. S. and Prakash, H. S. (2012) Bioactive potential of herbaceous phyllanthus species. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (S4). ISSN 0975 - 1491

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Abstract

Phyllanthus species are the most valued medicinal plants, extensively used in liver disorders. Ethanolic fractions of seven herbaceous species of Phyllanthus namely, P. amarus, P. debilis, P. maderaspatensis, P. virgatus, P. urinaria, P. scabrifolius and P. tenellus were tested for their in vitro antioxidant and DNA protection properties. Antioxidant properties were assessed by 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2'-azino-bis 3- thylbenzthiazoline-6-sulphonic acid (ABTS) and superoxide anion scavenging assay. The total phenolic content in the ethanolic fractions were measured by Folin-Ciocalteu assay. Ethanolic fractions of seven Phyllanthus species were tested for pTZ57R/T plasmid DNA protection against hydroxyl radicals. In addition, we have also carried out preliminary in vivo longevity studies on Drosophila melanogaster supplemented with ethanolic crude extract of P. amarus and P. debilis. In vitro antioxidant assay results for ethanolic fractions of Phyllanthus species clearly showed concentration-dependent increase in activity in relation to phenolic compounds. These fractions also protect the pTZ57R/T plasmid DNA damage induced by hydroxyl radicals. Results from preliminary longevity studies in D. melanogaster indicates nearly 50% increase in life span in Phyllanthus extract treated groups compared to control. In conclusion, our study clearly demonstrated that herbaceous Phyllanthus species have good antioxidant, DNA protection and life span extension properties.

Item Type: Article
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: MUL SWAPNA user
Date Deposited: 19 Aug 2019 06:04
Last Modified: 19 Aug 2019 06:04
URI: http://eprints.uni-mysore.ac.in/id/eprint/6742

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