Microwave-assisted solvent-free synthesis of n-alkyl benzotriazole derivatives: antimicrobial studies

Ningegowda, Raghu and Kavitha, C. V. and Priya, B. S. and Gaonkar, S. L. and Tejesvi, M. V. and Rangappa, K. S. and Swamy, Nanjunda S. (2009) Microwave-assisted solvent-free synthesis of n-alkyl benzotriazole derivatives: antimicrobial studies. LETTERS IN DRUG DESIGN & DISCOVERY, 6 (7). pp. 502-507. ISSN 1875-628X

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Official URL: http://doi.org/10.2174/157018009789108222

Abstract

To elucidate further our structural activity relation on the chemistry and antimicrobial activity, a series of novel N-alkylated benzotriazole derivatives bearing pharmaceutically important substituted biphenyl and benzyl halides were synthesized. The synthesized compounds were characterized and tested for in vitro antimicrobial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms. The synthesis has been carried out using microwave irradiation method with solvent and without solvent. The obtained results showed high yields. Interestingly, compounds 2a and 2b showed a two fold increased antibacterial activity than the standard drug tested and the compounds 2d and 2e showed potent antifungal activity than the standard drug tested.

Item Type: Article
Uncontrolled Keywords: Benzotriazole; N-alkylation; Solvent-free; Microwave irradiation; Antimicrobials
Subjects: B Life Science > Biotechnology
C Chemical Science > Chemistry
Depositing User: Shrirekha N
Date Deposited: 17 Aug 2019 11:46
Last Modified: 17 Aug 2019 11:46
URI: http://eprints.uni-mysore.ac.in/id/eprint/6716

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