Jayashankar, B. and Rai, K. M. Lokanatha and Baskaran, N. and Sathish, H. S. (2009) Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents. European Journal of Medicinal Chemistry, 44 (10). pp. 3898-3902. ISSN 1768-3254
Full text not available from this repository. (Request a copy)Abstract
A series of novel ether-linked bis(heterocycle)s have been synthesized via 3 + 2]-cycloaddition reaction of nitrile oxide with allyl alcohol followed by intramolecular 1,3-diploar cycloaddition reaction of nitrite imine with carbonyl group. All the newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Among the list of compounds (7a-k) studied, 7d, 7g, 7j, and 7k exhibited excellent activity comparable to ibuprofen and aspirin at the similar dosages. (C) 2009 Elsevier Masson SAS. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Bis(heterocycle); Anti-inflammatory; Analgesic; 1,3,4-Oxadiazole; Chloramine-T |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 17 Aug 2019 10:30 |
| Last Modified: | 13 Jan 2023 11:02 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/6689 |
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