Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines

Khanum, Shaukath Ara and Noor Fatima Khanum and Shashikanth, M. (2008) Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines. Bioorganic & Medicinal Chemistry Letters, 18 (16). 4597 - 4601. ISSN 1464-3405

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Official URL: https://doi.org/10.1016/j.bmcl.2008.07.029

Abstract

A series of potential biologically active 2-aryloxy methyl oxazolines 3a–n have been synthesized from substituted hydroxybenzenes 1a–n with good chemical yield. The compounds 3a–n were screened for their anti-inflammatory, ulcerogenic, cyclooxygenase activities and also for their acute toxicity. The potency of the compounds was compared with that of the standard drugs, aspirin and phenyl butazone. The outcome indicates that compounds 3b (48.2), 3h (48.5) and 3l (46.5) offered significant anti-inflammatory activity with low ulcerogenic activity than the standard drugs.

Item Type: Article
Uncontrolled Keywords: Oxazolines, Anti-inflammatory, Ulcerogenic, Cyclooxygenase, Acute toxicity
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 17 Aug 2019 09:50
Last Modified: 17 Aug 2019 09:50
URI: http://eprints.uni-mysore.ac.in/id/eprint/6668

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