Dinesh, N. D. and Nagaraja, P. and Rangappa, K. S. (2004) A sensitive spectrophotometric assay for tinidazole and metronidazole using a Pd-C and formic acid reduction system. TURKISH JOURNAL OF CHEMISTRY, 28 (3). pp. 335-343.
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Abstract
A simple, sensitive and rapid spectrophotometric method for the determination of tinidazole (TZ) and metronidazole (MZ) in pure as well as in dosage form is described. The method is based on the reduction of the nitro group of drugs using a novel and versatile reduction system comprising 10% PdG and formic acid. The resulting amine was then subjected to a, condensation reaction with sodium 1,2-naphthaquinone-4-sulfonate (NQS) to form red Schiff base with an absorption maximum at 510 nm. Beer's law was obeyed in the concentration ranges 2.0 to 45.0 mug mL(-1) and 1.5 to 37.0 mug mL(-1) with a limit of detection (LOD) of 0.44 mug mL(-1) and 0.36 mug mL(-1) for TZ and MZ, respectively. Other statistical analyses such as Student's t test and F test values are included. The sensitivity of the method surpasses that of the reported spectrophotometric methods. The method was successfully applied for the assay of different tablets, suspensions and injections of TZ and MZ.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | spectrophotometry; tinidazole; metronidazole; pharmaceutical formulations |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 19 Aug 2019 12:17 |
| Last Modified: | 17 Dec 2019 10:01 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/6662 |
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