Selective antifungal activity of shorter active analogues of Bactenecin7 against Fusarium mondiforme

Abiraj, K. and Sachidananda, M. K. and Prakasha Gowda, A. S. and Channe Gowda, D. (2004) Selective antifungal activity of shorter active analogues of Bactenecin7 against Fusarium mondiforme. Indian Journal Of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry, 43 (3). pp. 649-654. ISSN 0376-4699

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Abstract

Bactenecin7 (Bac7), a cationic antibacterial peptide, contains a repeating region of Xaa-Pro-Arg-Pro (Xaa=hydrophobic residue). To investigate the structure and property of a Pro/Arg-rich region, we synthesized a series of peptides, Xaa-Pro-Arg-Pro (Xaa=Gly, Arg, Leu, Ile, and Phe) as models and characterized. The conformational preferences of these peptides in water and trifluoroethanol have been examined by circular dichroism. The results suggest the presence of largely poly(Pro)-II helical conformation in aqueous and trifluoroethanol solutions. Their antifungal activity against Aspergillus niger, Aspergillus flavus and Fusarium moniliforme have been measured at various peptide concentrations. All the synthetic tetrapeptide fragments efficiently inhibit the growth of Fusarium moniliforme at the concentration level of 8-10 mug/mL, but failed to inhibit the growth of Aspergillus niger and Aspergillus flavus.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	26 Aug 2019 09:45
Last Modified:	16 Jul 2022 06:31
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6609

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