High performance liquid chromatographic determination of astemizole in pharmaceutical dosage forms

Basavaiah, K. and Charan, V. S. and Chandrashekar, U. (2004) High performance liquid chromatographic determination of astemizole in pharmaceutical dosage forms. Indian Journal of Chemical Technology, 11 (4). pp. 504-508. ISSN 0971-457X

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Abstract

A rapid, highly sensitive high performance liquid chromatographic method has been developed for the determination of astemizole that is suitable for routine use in quality control. The chromatographic conditions comprised of a reversed-phase C-18 column (250 X 4.6 mm) with a mobile phase of acetonitrile - 0.1% orthophosphoric acid, pH adjusted to 3.9 (80:20 v/v). The flow rate was 1.5 mL min(-1) and uv detection was set at 215 nm. The calibration graph was linear from 5.13 - 405.0 mug mL(-1). The method was validated according to ICH guidelines including the assay of commercially available tablets. Recoveries ranged from 98.10 to 101.90%. The utility and accuracy of the method were further established by parallel determination by a reference method and by recovery studies. The excipients present in the tablets did not interfere.

Item Type: Article
Uncontrolled Keywords: astemizole determination; HPLC; dosage forms
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 03 Sep 2019 07:23
Last Modified: 03 Sep 2019 07:23
URI: http://eprints.uni-mysore.ac.in/id/eprint/6571

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