Novel delta(2)-isoxazolines as group II phospholipase A(2) inhibitors

Basappa and Kumar, M. S. and Swamy, S. N. and Mahendra, M. and Shashidhara Prasad, J. and Viswanath, B. S. and Rangappa, K. S. (2004) Novel delta(2)-isoxazolines as group II phospholipase A(2) inhibitors. Bioorganic & Medicinal Chemistry Letters, 14 (14). pp. 3679-3681. ISSN 0960-894X

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The synthesized imidazolyl substituted delta(2)-isoxazolines were subjected to Phospholipase A(2) (PLA(2)) enzyme inhibitory activity against snake venom source and their structure-activity relationship with respect to different groups attached to this moiety is reported for the first time. The crystal structure of the compound 2-butyl-5-chloro-3H-imidazolyl-4-carbaldehyde oxime 2, an intermediate for the construction of isoxazolines is reported. These compounds exerted a significant PLA2 enzyme inhibitory activity against group II PLA2. The in vivo activity on mice of selected compounds 3bI and 3bIV shows the comparable anti-inflammatory activity with the known standard ursolic acid. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: delta(2-)isoxazoline; aldoxime; phospholipase A(2); anti-inflammatory; ursolic acid
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 31 Aug 2019 09:02
Last Modified: 22 Nov 2022 09:43

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