Basappa and Kumar, M. S. and Swamy, S. N. and Mahendra, M. and Shashidhara Prasad, J. and Viswanath, B. S. and Rangappa, K. S. (2004) Novel delta(2)-isoxazolines as group II phospholipase A(2) inhibitors. Bioorganic & Medicinal Chemistry Letters, 14 (14). pp. 3679-3681. ISSN 0960-894X
Full text not available from this repository. (Request a copy)Abstract
The synthesized imidazolyl substituted delta(2)-isoxazolines were subjected to Phospholipase A(2) (PLA(2)) enzyme inhibitory activity against snake venom source and their structure-activity relationship with respect to different groups attached to this moiety is reported for the first time. The crystal structure of the compound 2-butyl-5-chloro-3H-imidazolyl-4-carbaldehyde oxime 2, an intermediate for the construction of isoxazolines is reported. These compounds exerted a significant PLA2 enzyme inhibitory activity against group II PLA2. The in vivo activity on mice of selected compounds 3bI and 3bIV shows the comparable anti-inflammatory activity with the known standard ursolic acid. (C) 2004 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | delta(2-)isoxazoline; aldoxime; phospholipase A(2); anti-inflammatory; ursolic acid |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 31 Aug 2019 09:02 |
| Last Modified: | 22 Nov 2022 09:43 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/6565 |
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