Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents

Khanum, S. A. and Venu, T. D. and Shashikanth, S. and Firdouse, A. (2004) Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents. bio-organic and medicinal chemistry letters, 14 (21). pp. 5351-5355. ISSN 0960-894X

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Official URL: doi:10.1016/j.bmcl.2004.08.014

Abstract

Benzoylation of hydroxybenzophenones 1a-f affords substituted benzoyl phenyl benzoates 3a-f, which on Fries rearrangement using microwave irradiation led to a facile synthesis of solely dibenzoyl phenols 4a-f in excellent yield. The newly synthesized compounds were screened for their anti-inflammatory activity and were compared with standard drugs. Out of the compounds studied, the compound 4e showed more potent activity than the standard drugs at all doses tested. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: synthesis-; dibenzoyl phenols; anti-inflammatory activity
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: lpa venkatesh user
Date Deposited: 03 Sep 2019 12:38
Last Modified: 03 Sep 2019 12:38
URI: http://eprints.uni-mysore.ac.in/id/eprint/6526

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