Discrimination in partnership: compartment-specific interactions of Hox proteins

Guruharsha, K. G. and Vijay Raghavan, K. (2004) Discrimination in partnership: compartment-specific interactions of Hox proteins. Journal of Genetics, 83 (3). pp. 223-226. ISSN 0022-1333

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Abstract

A relatively small number of regulatory proteins perform multiple functions to orchestrate the develo pment of an animal from a zygote. Many regulatory proteins are tra n- scription factors that affect the expression of dow nstream genes. These factors interact with other proteins in the nucleus to regulate expression of their target genes. The main effect of loss -of-function mutations in genes encod- ing major regulators of develop ment is lethality at the earliest stage where the regulatory molecule is r equired. Many, very important roles of regulatory factors have been inferred from these lethal phenotypes. Ho wever, the early lethality means that u nderstanding the later roles, if any, of such genes becomes difficult. In addition, loss -of- function studies alone do not usually provide insights into the identity and role of interacting proteins critical for the final output of the regulatory si gnal.

Item Type:	Article
Uncontrolled Keywords:	Hox proteins; segmentation genes; cis-elements; binding domain; repressor; gene regulation
Subjects:	B Life Science > Zoology
Divisions:	Department of > Zoology
Depositing User:	Users 23 not found.
Date Deposited:	04 Sep 2019 12:15
Last Modified:	30 Jun 2020 10:15
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6514

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