Antiangiogenic and growth inhibitory effects of synthetic novel 1, 5-diphenyl-1,4 pentadiene-3-one-3-yl-ethanone pyridine curcumin analogues on Ehrlich ascites tumor in vivo

Chandru, H. and Sharada, A. C. and Ananda Kumar, C. S. and Rangappa, K. S. (2008) Antiangiogenic and growth inhibitory effects of synthetic novel 1, 5-diphenyl-1,4 pentadiene-3-one-3-yl-ethanone pyridine curcumin analogues on Ehrlich ascites tumor in vivo. Medicinal Chemistry Research, 17 (8). pp. 515-529. ISSN 1554-8120

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Abstract

In the present investigation we have synthesized novel substituted dienone pyridine ethanone curcumin analogues 3a and 3b by nucleophilic substitution reactions with 2-bromo-1-pyridine-3-yl ethanone and characterized by 1H nuclear magnetic resonance (NMR), infrared IR, mass, and CHNS analysis. The compounds demonstrated tumor growth inhibition and antiangiogenic effects against mouse Ehrlich ascites tumor in vivo and suppressed neovascularization in a chorio allantoic membrane model.

Item Type: Article
Subjects: C Chemical Science > Biochemistry
Divisions: Yuvaraj college > Bio-Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 17 Aug 2019 06:29
Last Modified: 17 Aug 2019 06:29
URI: http://eprints.uni-mysore.ac.in/id/eprint/6477

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