Synthesis and in vitro antiproliferative activity of diphenyl(piperidin-4- yl)thioamide methanol derivatives

Benaka Prasad, S. B. and Vinaya, M. K. and Ananda Kumar, C. K. S. and Swarup, S. and Rangappa, K. S. (2008) Synthesis and in vitro antiproliferative activity of diphenyl(piperidin-4- yl)thioamide methanol derivatives. Letters in Drug Design & Discovery, 5 (7). pp. 454-461. ISSN 1875-628X

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Abstract

A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-j) were synthesized and characterized by 1H NMR, LC/MS, FTIR and elemental analyses. All the compounds synthesised were evaluated for their cell antiproliferation activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The antiproliferative effects of the synthesised compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines namely HeLa, HT-29, MCF-7, HepG-2 by adopting positive and negative control. The importance of the methoxy and fluorine group on diphenyl(piperidin-4-yl)methanol moiety was confirmed and it was noted that, the substitution at 4th position of the aryl ring plays a dominant role and was responsible for the antiproliferative activity. Among the synthesized compounds, only (10a) and (10b) have potent antiproliferative activity on all the carcinoma cell lines tested.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: manjula User
Date Deposited: 17 Aug 2019 06:21
Last Modified: 17 Aug 2019 06:21
URI: http://eprints.uni-mysore.ac.in/id/eprint/6471

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