Benaka Prasad, S. B. and Vinaya, M. K. and Ananda Kumar, C. K. S. and Swarup, S. and Rangappa, K. S. (2008) Synthesis and in vitro antiproliferative activity of diphenyl(piperidin-4- yl)thioamide methanol derivatives. Letters in Drug Design & Discovery, 5 (7). pp. 454-461. ISSN 1875-628X
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A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-j) were synthesized and characterized by 1H NMR, LC/MS, FTIR and elemental analyses. All the compounds synthesised were evaluated for their cell antiproliferation activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The antiproliferative effects of the synthesised compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines namely HeLa, HT-29, MCF-7, HepG-2 by adopting positive and negative control. The importance of the methoxy and fluorine group on diphenyl(piperidin-4-yl)methanol moiety was confirmed and it was noted that, the substitution at 4th position of the aryl ring plays a dominant role and was responsible for the antiproliferative activity. Among the synthesized compounds, only (10a) and (10b) have potent antiproliferative activity on all the carcinoma cell lines tested.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 17 Aug 2019 06:21 |
| Last Modified: | 17 Aug 2019 06:21 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/6471 |
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