Reversible antifertility effect of Cyamposis psoralioides in male swiss albino mice

Thejashwini, M. S. and Krishna Ram, H. and Shivabasavaiah (2012) Reversible antifertility effect of Cyamposis psoralioides in male swiss albino mice. International Journal of Advanced Biological Research, 2 (4). pp. 657-665. ISSN 2250-3560

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Abstract

Present study was undertaken to evaluate the reversible antifertility effect of Cyamposis psoralioides (Guar gum) pod on male Swiss albino mice. The mice were orally administered the ethanol crude extract (200mg/Kg body weight and 400mg/Kg body weight) for 40 days. Effect of the treatment on reproductive organs and fertility was investigated and the testosterone level was determined by RIA. The results revealed that the low dose of 200mg/Kg body weight treatment caused 50% reduction in the fertility of male mice, whereas in high dose 400mg/Kg body weight caused 100% reduction in the fertility of male mice. The treatment caused reduction in the number of spermatozoa in cauda epididymis (P<0.001, P<0.001). The weight of reproductive organs viz., testis (P<0.001, P<0.001), epididymis (P<0.01, P<0.01), seminal vesicle (P<0.05, P<0.001), vas deferens (P<0.001) and ventral prostate (P<0.001, P<0.001) decreased significantly. Serum testosterone level reduced significantly (P<0.001, P<0.001) when compared to the control group. Histometry showed reduction in the diameter of seminiferous tubules (P<0.001, P<0.001) and diameter of the Leydig cells (P<0.001, P<0.001). Biochemical parameters of testis like total protein (P<0.05, P<0.05), Cholesterol (P<0.05, P<0.05), ascorbic acid (P<0.01, P<0.05) and glycogen (P<0.01, P<0.001) showed statistical significant differences when compared to the control group. Both the groups of animals were maintained for 30 days without any treatment to check the reversibility. All the animals after the recovery period showed normal fertility rate. From this we can conclude that guar gum can be used as a potent antifertility agent.

Item Type:	Article
Subjects:	B Life Science > Zoology
Divisions:	Department of > Zoology
Depositing User:	C Swapna Library Assistant
Date Deposited:	17 Aug 2019 05:38
Last Modified:	17 Aug 2019 05:38
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6456

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