Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents

Dinesha and Viveka, S. and Priya, I. K. and Pai, K. S. R. and Naveen, S. and Lokanath, N. K. and Nagaraja, G. K. (2015) Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents. European Journal of Medicinal Chemistry, 104. pp. 25-32. ISSN 0223-5234

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Official URL: http://doi.org/10.1016/j.ejmech.2015.09.029

Abstract

Breast cancer is probably the most prevalent cancer in women. The development of resistance to therapeutic agents and lack of targeted therapy for breast cancer cells provide motivation to identify new compounds for the treatment. With this objective in mind, a new series of 3-fluoro-4-methoxyphenyl group based 1,3,5-trisubstituted aryl-5-hydroxypyrazoline analogues 4a-l was synthesized through multi-step reaction sequence. The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR, LC-MS and elemental analysis. They were screened for their in vitro anticancer and in vitro antioxidant activities. Among the tested compounds 4h, 4c and particularly 4i displayed promising cytotoxic effect on breast cancer cell lines. The compounds were also found to possess antioxidant activity when tested against DPPH free radical. Overall, this work has contributed to the development of promising leads for anticancer and antioxidant activities. (C) 2015 Elsevier Masson SAS. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Synthesis; Hydroxypyrazolines; Characterization; Anticancer activity; Antioxidant activity
Subjects: D Physical Science > Physics
Divisions: Department of > Physics
Depositing User: Shrirekha N
Date Deposited: 29 May 2019 10:22
Last Modified: 17 Sep 2019 10:21
URI: http://eprints.uni-mysore.ac.in/id/eprint/638

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