Synthesis and antimicrobial activity of amino acids conjugated diphenylmethylpiperazine derivatives

Shivakumara, K. N. and Prakasha, K. C. and Channe Gowda, D. (2009) Synthesis and antimicrobial activity of amino acids conjugated diphenylmethylpiperazine derivatives. E-JOURNAL OF CHEMISTRY, 6 (1). S473-S479. ISSN 0973-4945

Text (Full Text) CHE_2009_Shivakumara.pdf - Published Version Download (1MB)

Abstract

A series of amino acid conjugated diphenylmethylpiperazine derivatives were synthesized by coupling diphenylmethylpiperazine with different Boc-amino acids using EDCI/HOBt as coupling agent and NMM as base. The synthesized compounds were characterized by (1)H-NMR and elemental analysis. The Boc-deblocked derivatives were tested for their antimicrobial activity. We are here reporting that Phe and Trp conjugated diphenylmethylpiperazine showed equally good antibacterial activities as that of conventional antimicrobial drugs.

Item Type:	Article
Uncontrolled Keywords:	Antimicrobial drugs; Diphenylmethylpiperazine (Benzhydrilpiperazine); Conjugated amino acids and Synthesis
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 19 not found.
Date Deposited:	14 Aug 2019 07:44
Last Modified:	14 Nov 2019 10:07
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6366

Actions (login required)

View Item