Synthesis and characterization of substituted ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate derivatives as antioxidant agents

Asha, D. and Malviya, Manish and Chandrappa, S. and Sadashiva, C. T. and Vinaya, K. and Prasanna, D. S. and Rangappa, K. S. (2009) Synthesis and characterization of substituted ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate derivatives as antioxidant agents. LETTERS IN DRUG DESIGN & DISCOVERY, 6 (8). pp. 637-643. ISSN 1875-628X

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Official URL: http://doi.org/10.2174/157018009789353509

Abstract

A series of novel ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxy-pyrimidine-4-carboxylate derivatives 8(a-i) were synthesized by nucleophilic substitution reaction of ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate (7) with different substituted aliphatic/aromatic sulfonyl chlorides (R-SO2-Cl). All the synthesized compounds were characterized by IR, H-1 NMR and LC/MS analysis. The synthesized compounds were evaluated for their antioxidant activity by diphenylpicrylhydrazyl (DPPH) assay and also by hydroxy radical induced DNA strand scission assay. Among the synthesized compounds 8c, 8f and 8i showed promising antioxidant activity.

Item Type: Article
Uncontrolled Keywords: Benzyl 1-cyanocyclobutylcarbamate; Pyrimidine; Hydroxy radical; DPPH Assay; Antioxidant
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 13 Aug 2019 09:36
Last Modified: 13 Aug 2019 09:36
URI: http://eprints.uni-mysore.ac.in/id/eprint/6326

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