Basavaiah, K. and Abdulrahman, S. A. M. and Vinay, K. B. (2009) Simple and sensitive spectrophotometric determination of olanzapine in pharmaceutical formulations using two sulphonphthalein acid dyes. Journal of Food and Drug Analysis, 17 (6). pp. 434-442. ISSN 1021-9498
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Two simple, sensitive and extraction-free spectrophotometric methods have been developed for the determination of olanzapine (OLP) both in pure form and in pharmaceutical formulations. The methods are based on the fort-nation of yellow coloured ion-pair complexes between OLP and two sulphonphthalein acid dyes, bromocresol purple (BCP) and bromothymol blue (BTB) with absorption maximum at 405 nm and 410 nm for BCP and BTB, respectively. The stoichiometry of the complex in either case was found to be 1: 1 and the conditional stability constant (K(F)) of the complexes has also been calculated. Reaction conditions were optimized to obtain the maximum colour intensity. Beer's law was obeyed in the concentration ranges of 1.0 - 10.0 and 1.0 - 8.0 mu g/mL with BCP and BTB, respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data. The proposed methods have been applied successfully to the analysis of OLP in pure form and in its dosage forms and no interference was observed from common excipients present in pharmaceutical formulations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | olanzapine; ion-pair complexes; bromocresol purple; bromothymol blue |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 13 Aug 2019 07:02 |
| Last Modified: | 23 Jun 2022 06:30 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/6314 |
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