The anti-ophidian properties of Anacardium occidentale bark extract

Ushanandini, S. and Nagaraju, S. and Nayaka, S. Chandra and Harish Kumar, K. and Kemparaju, K. and Girish, K. S. (2009) The anti-ophidian properties of Anacardium occidentale bark extract. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 31 (4). pp. 607-615. ISSN 1532-2513

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Official URL: http://doi.org/10.3109/08923970902911909

Abstract

Snakebites in rural areas of tropical and subtropical regions are commonly treated with medicinal plants. In this report, we have studied the ability of Anacardium occidentale bark extract to neutralize enzymatic as well as pharmacological effects induced by Vipera russelii venom. The extract neutralized the viper venom hydrolytic enzymes such as phospholipase, protease, and hyaluronidase in a dose dependent manner. These enzymes are responsible for both local effects of envenomation such as local tissue damage, inflammation and myonecrosis, and systemic effects including dysfunction of vital organs and alteration in the coagulation components. In addition, extract neutralized the pharmacological effects such as edema, hemorrhage, and myotoxic effects including lethality, induced by venom. Since, it inhibits both hydrolytic enzymes and pharmacological effects; it may be used as an alternative treatment to serum therapy and, in addition, as a rich source of potential inhibitors of hydrolytic enzymes involved in several physiopathological diseases.</.

Item Type: Article
Subjects: B Life Science > Biotechnology
C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Department of > Biotechnology
Depositing User: Shrirekha N
Date Deposited: 13 Aug 2019 05:23
Last Modified: 13 Aug 2019 05:23
URI: http://eprints.uni-mysore.ac.in/id/eprint/6303

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