Antiangiogenic effect of 2-benzoyl--phenoxy acetamide in EAT cell is mediated by HIF-1α and down regulation of VEGF of in-vivo

Prabhakar, B. T. and Shaukath Ara Khanum and Shashikanth, S. and Bharathi P. Salimath (2006) Antiangiogenic effect of 2-benzoyl--phenoxy acetamide in EAT cell is mediated by HIF-1α and down regulation of VEGF of in-vivo. Investigational New Drugs, 24 (6). pp. 471-478. ISSN 1573-0646

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Abstract

Benzophenones and its analogues are known for wide range of biological properties. Synthetic benzophenone analogue 2-benzoyl -phenoxy acetamide (BP-1) is proven to be potent antitumor and proapoptotic activity against EAT cells in-vivo. In the present report, we studied the antiangiogenic effect of BP-1 in EAT cells induced angiogenesis. Treatment with BP-1 in-vivo was demonstrated by the down regulation of the secretion of VEGF from EAT cells and inhibition of blood vessels formation indicating the potential angioinhibitory effect of BP-1 in EAT cells. HIF-1α protein, a transcription factor known to be key a regulator in hypoxia-induced angiogenesis was also down regulated by BP-1. Our findings indicated that, HIF-1α nuclear sequestration is repressed by BP-1 through inhibition of nuclear translocation. We postulate that diminished HIF-1α nuclear presence and activity in BP-1 treated EAT cells could be responsible for decreased VEGF expression and antiangiogenic effects.

Item Type:	Article
Subjects:	B Life Science > Botany
Divisions:	Department of > Botany
Depositing User:	LA manjunath user
Date Deposited:	12 Aug 2019 07:10
Last Modified:	20 Jun 2022 10:31
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6273

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