Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides

Priya, B. S. and Nanjunda Swamy, S. and Tejesvi, M. V. and Basappa and Sarala, G. and Gaonkar, Santosh L. and Naveen, S. and Shashidhara Prasad, J. and Rangappa, K. S. (2006) Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides. European Journal of Medicinal Chemistry, 41 (11). 1262 - 1270. ISSN 1768-3254

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Abstract

A new class of benzamide derivatives 3a(I–VI) and 3b(I–VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3bII showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-4-(thiazol-2-yl-sulfamoyl)-phenyl-benzamide 3aII and 2-(2-(2-ethoxybenzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P21 and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding.

Item Type:	Article
Uncontrolled Keywords:	Benzamide, Antibacterial, Antifungal, Monoclinic, Triclinic
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	12 Aug 2019 07:00
Last Modified:	18 Jul 2022 10:20
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6270

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