An efficient synthesis of 1,5-thiadiazepines and 1,5-benzodiazepines by microwave-assisted heterocyclization

Nagaraja, G. K. and Vaidya, Vijayavittala P. and Rai, K. S. and Kittappa, M. (2006) An efficient synthesis of 1,5-thiadiazepines and 1,5-benzodiazepines by microwave-assisted heterocyclization. Phosphorus, Sulfur, and Silicon and the Related Elements, 181 (12). pp. 2797-2806. ISSN 1563-5325

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Abstract

A novel and efficient method for the synthesis of substituted thiazepines and diazepines has been developed. A simple one-pot reaction of chalcones 1a-f with 1-amino-2-mercapto-5-phenyl-1,3,4-triazole and o-phenylenediamine in the presence of a catalytic amount of sodium acetate under microwave irradiation gave 2-(3,8-diphenyl-7,8-dihydro[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepin-6-yl)phenoles 2a-f and 2-(2-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-4-yl)phenoles 3a-f, respectively. The structure of all the synthesized compounds was elucidated on the basis of elemental analysis, IR, H-1 and C-13 NMR, and mass spectral data.

Item Type:	Article
Subjects:	M Polymer Science > Polymer Science
Divisions:	PG Centre Mandya > Polymer Science
Depositing User:	LA manjunath user
Date Deposited:	12 Aug 2019 05:47
Last Modified:	13 Jan 2023 11:04
URI:	http://eprints.uni-mysore.ac.in/id/eprint/6254

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