Evaluation and studies on the structural impact of substituted 4, 5-Dihydroisoxazoles on their biological activities

Ajay Kumar, K. and Lokeshwari, D. M. and Vasanth Kumar, G. (2012) Evaluation and studies on the structural impact of substituted 4, 5-Dihydroisoxazoles on their biological activities. International Journal of Pharmaceutical Sciences and Drug Research, 4 (3). pp. 236-239. ISSN 0975-248X

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Abstract

In present study, a series of isoxazole derivatives synthesized were evaluated for antimicrobial activities by disc diffusion method. Some compounds of the series exhibited promising antibacterial and antifungal activity compared to standard drugs. The minimum inhibitory concentration (MIC’s) was determined against each organism. The compounds were tested for their in-vitro antioxidant activity and reducing power ability. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of an antimicrobial, anti-oxidant study, the effect of substitution on the activity and possible structure activity relationship of the compounds for their antioxidant activity is presented.

Item Type: Article
Uncontrolled Keywords: Isoxazoles, Antibacterial, Antifungal, Antioxidant, Reducing power
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 08 Aug 2019 07:36
Last Modified: 08 Aug 2019 07:36
URI: http://eprints.uni-mysore.ac.in/id/eprint/6240

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