A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4R alpha) & toll-like receptor 4 (TLR4) genes with asthma in Indian adults

Davoodi, P. and Mahesh, P. A. and Holla, A. D. and Ramachandra, N. B. (2015) A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4R alpha) & toll-like receptor 4 (TLR4) genes with asthma in Indian adults. Indian Journal of Medical Research, 142. pp. 674-679.

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Abstract

Background & objectives: Interleukin 4 (IL4) and IL13 genes are believed to be responsible for inflammation of the airways in asthmatics. These share a common receptor component called IL4R alpha which is another potentially important candidate gene linked to asthma phenotypes. Another gene Toll-like receptor 4 (TLR4) might affect the incidence or progression of asthma through the expression of proinflammatory genes. Several single nucleotide polymorphisms (SNPs) in IL4, IL13, IL4R alpha and TLR4 have been reported to be linked to asthma or related phenotypes in several ethnic populations using linkage studies and association studies. However, the results have not been consistent. We investigated five SNPs (C-589T and C-33T of IL4, G+2044A of IL13, A+1902G of IL4R alpha, and A+896G of TLR4) in patients with adult onset asthma to evaluate their role in manifestation and severity of asthma. Methods: Adult (>18 yr of age) patients with asthma (n=100) and healthy controls (n=50) were included in the study. Genotyping was performed using sequenom MassARRAY technology. Results: The mutant alleles of the C-589T and C-33T SNPs in the promoter region of IL4 were present in 4 per cent patients with asthma but absent from the control group suggesting that the variations in IL4 may contribute to asthma occurrence. The SNPs of other genes were seen in both controls and patients. Interpretation & conclusions: The results suggest the possible association between the genetic distribution of C-589T and C-33T SNPs of IL4 with asthma in Indian adults.

Item Type:	Article
Uncontrolled Keywords:	Allele; asthma; cytokine; genes; interleukin; SNPs; TLR4
Subjects:	B Life Science > Zoology
Divisions:	Department of > Zoology
Depositing User:	Users 19 not found.
Date Deposited:	28 May 2019 11:13
Last Modified:	17 Sep 2019 10:00
URI:	http://eprints.uni-mysore.ac.in/id/eprint/603

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