Synthesis and antioxidant properties of some novel 5H-dibenzb,fazepine derivatives in different in vitro model systems

Vijay Kumar, H. and Naik, Nagaraja (2010) Synthesis and antioxidant properties of some novel 5H-dibenzb,fazepine derivatives in different in vitro model systems. European Journal of Medicinal Chemistry, 45 (1). 2 - 10. ISSN 1768-3254

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Abstract

A series of 5H-dibenzb,fazepine containing different aminophenols and substituted aminophenols were synthesized. 3-chloro-1-(5H-dibenzb,fazepine-5yl)propan-1-one (2) was obtained by N-acylation of 5H-dibenzb,fazepine (1) with 3-chloro propionyl chloride. Further base condensation with different aminophenols and substituted aminophenols to produce series of 5H-dibenzb,fazepine containing aminophenol and substituted aminophenol (2a–e). The structures of newly synthesized compounds were characterized by spectral and elemental analysis. Their antioxidant properties were evaluated by using several methods: scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, inhibition of lipid peroxidation using β-carotene linoleate system, inhibition of human low-density lipoprotein (LDL) oxidation and reducing power. Butylated Hydroxy Anisole (BHA) and Ascorbic acid (AA) were used as the reference antioxidant compounds and also the comparative study with the synthesized compounds was done. Under our experimental conditions, Compound (2) showed negligible activity over all the antioxidant assays but 5H-dibenzb,fazepine containing different aminophenols and substituted aminophenols (2a–e) showed good antioxidant activities over all the methods and compounds containing substituted aminophenols 2e and 2d showed predominant antioxidant activities among the synthesized analogues.

Item Type:	Article
Uncontrolled Keywords:	3-Chloro-1-(5H-dibenzb,fazepine-5yl)propan-1-one, Aminophenol, Substituted aminophenols, Antioxidant activity
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	28 Jul 2019 11:09
Last Modified:	23 Dec 2019 10:19
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5971

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