Novel organotin(IV)-schiff base complexes: synthesis, characterization, antimicrobial activity, and DNA interaction studies

Prasad, K. S. and Kumar, L. S. and Prasad, M. and Revanasiddappa, H. D. (2010) Novel organotin(IV)-schiff base complexes: synthesis, characterization, antimicrobial activity, and DNA interaction studies. Bioinorganic Chemistry and Applications (854514). pp. 1-9. ISSN 1687-479X

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Abstract

Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino) isoindoline-1,3-dione (L-1), and 4-(4-hydroxy-3-methoxy-benzylideneamino-N-(pyrimidin-2-yl) benzenesulfonamide (L-2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes 1 and 3 with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes 1 and 3 with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex 1 can act as effective DNA cleaving agent when compared to complex 3 resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	28 Jul 2019 05:35
Last Modified:	11 Dec 2019 10:38
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5957

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