An overview on nucleases (DNase, RNase, and Phosphodiesterase) in Snake venoms

Dhananjaya, B. L. and D'Souza, C. J. M. (2010) An overview on nucleases (DNase, RNase, and Phosphodiesterase) in Snake venoms. Biochemistry Moscow, 75 (1). pp. 1-6. ISSN 0006-2979

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In this review, we have compiled the data on pharmacological activities associated with endogenous purine release related enzymes-nucleases (DNases, RNases, and phosphodiesterases). The results of studies on toxic effects of these enzymes, emphasizing the future directions in this field, are summarized. One of the major problems facing toxicologists is the identification and characterization of specific venom nucleases since they share similar substrate specificities and bio-chemical properties. In this review, we have attempted to clarify some of the discrepancies about these enzymes. Further, we have tried to correlate the existence of nuclease enzymes in relation to endogenous release of purines, a multitoxin, during snake envenomation, and we also discuss the possible actions of purines. We hope that this review will stimulate renewed interest among toxicologists to biologically characterize these enzymes and elucidate their role in envenomation.

Item Type: Article
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: LA manjunath user
Date Deposited: 28 Jul 2019 05:27
Last Modified: 28 Jul 2019 05:27

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