Efficacy of bioactive compounds from Curcuma aromatica against mosquito larvae

Madhu, S. K. and Shaukath Ara Khanum and Vijayan, V. A. (2010) Efficacy of bioactive compounds from Curcuma aromatica against mosquito larvae. Acta Tropica, 113 (1). 7 - 11. ISSN 1873-6254

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With the development of resistance to conventionally used synthetic insecticides, vector management has become acutely problematic. Hence more attention has been focused on botanicals. Therefore our present study was aimed to evaluate the efficacy of extracts from rhizomes of Curcuma aromatica against the larvae of filariasis vector mosquitoes, Culex quinquefasciatus employing standard WHO procedure at Mysore. The soxhlet extraction was carried out using non-polar organic solvent, petroleum ether. The efficacy of petroleum ether extract seemed to be effective with LC50 and LC90 values of 11.42 and 18.00ppm respectively. Bioassay-guided fractionation through flash chromatography lead to the isolation of two larvicidal compounds namely 9-oxoneoprocurcumenol and neoprocurcumenol. Between the two, 9-oxoneoprocurcumenol exerted significant toxicity (P<0.01) on mosquito larvae with LC50 value of 5.81ppm and LC90 being 9.99ppm compared to neoprocurcumenol with 13.69 and 23.92ppm of LC50 and LC90 values respectively. From the results, C. aromatica could be considered as one of the powerful candidate to bring about useful botanicals so as to prevent the resurgence of mosquito vectors.

Item Type: Article
Uncontrolled Keywords: , Larvicidal activity, , 9-Oxoneoprocurcumenol, Neoprocurcumenol
Subjects: B Life Science > Zoology
Divisions: Department of > Zoology
Depositing User: LA manjunath user
Date Deposited: 28 Jul 2019 05:00
Last Modified: 24 Nov 2022 06:18
URI: http://eprints.uni-mysore.ac.in/id/eprint/5953

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