Statistical analysis of antimicrobial data of 2-[2-(aroyl) aroyloxy]methyl1, 3, 4 oxadiazoles analogues using ANOVA

Hezam, Al-Ostoot Fares and Vidya, R. and Zabiulla and Eissa, Mohammed Yassr Husein and Jyothi Mahima and Pallavi, H. M. and Shaukath Ara, K. (2018) Statistical analysis of antimicrobial data of 2-[2-(aroyl) aroyloxy]methyl1, 3, 4 oxadiazoles analogues using ANOVA. Asian Journal of Research in Chemistry, 11 (2). pp. 293-297. ISSN 0974-4150

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Official URL: https://doi.org/10.5958/0974-4150.2018.00055.X

Abstract

Heterocyclic chemistry has become one of the most important fields of research in pharmaceutical industry due to their many fold applications. Amongst all, heterocyclic molecules containing nitrogen and oxygen (like oxadiazole ring system) have shown most potent biological activities. Microorganisms are strictly attendant with the fitness and well-being of human beings. The present treatments of bacterial and fungal infections are a bit unsatisfactory, owing to rapidly developing drug resistance and side effects. The improved of antibacterial and antifungal agents results in resistant to drugs. A series of substituted Oxadiazoles analogues 4a-jwere synthesized and screened for their antibacterial and antifungal activities to evaluate zone of inhibition. The significant effect ofin-vitroantimicrobial and antifungal activities of compounds 4a-jwere studied using one way ANOVA. It was shown that the variables 4a-j series weresignificant. Further pairwise comparison of significant differences between the variables were analyzed using Tukey HSD. The data revels that compound 4a with 2-methyl and 3chloro group in phenyl and benzoyl ring respectively, have shown excellent activity and more potent among the 4a-j series.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Yuvaraj college > Statistics
Depositing User: manjula User
Date Deposited: 27 Jul 2019 11:09
Last Modified: 27 Jul 2019 11:16
URI: http://eprints.uni-mysore.ac.in/id/eprint/5946

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