Sensitive spectrophotometric determination of Atenolol in Pharmaceutical formulations using Bromate-Bromide mixture as an eco-friendly Brominating Agent

Prashanth, K. N. and Basavaiah, K. (2012) Sensitive spectrophotometric determination of Atenolol in Pharmaceutical formulations using Bromate-Bromide mixture as an eco-friendly Brominating Agent. Journal of Analytical Methods in Chemistry. ISSN 2090-8873

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Abstract

Three simple and sensitive spectrophotometric methods are proposed for the determination of atenolol (ATN) in bulk drug and tablets. The methods are based on the bromination of ATN by the bromine generated in situ by the action of the acid on the bromate-bromide mixture followed by the determination of unreacted bromine by reacting with a fixed amount of either metacresol purple (MCP) and measuring the absorbance at 540 nm (method A) and 445 nm (method B) or erioglaucine (EGC) and measuring the absorbance at 630 nm (method C). Beer's law is valid within the concentration ranges of 1.0-20.0, 2.0-40.0 and 1.0-8.0 mu g/mL for method A, method B and method C, respectively. The calculated molar absorptivities were found to be 1.20x10(4), 4.51x10(3) and 3.46 x 10(4) L/mol . cm for method A, method B and method C, respectively. Sandell's sensitivity values, correlation coefficients, limits of detection and quantification are also reported. Recovery results were statistically compared with those of a reference method by applying Student's t- and F-test. The novelty of the present study is the measurement of two different colors using MCP, that is, red-pink color of MCP in acid medium at 540 nm and yellowish-orange color of brominated MCP at 445 nm.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	26 Jul 2019 10:04
Last Modified:	26 Jul 2019 10:04
URI:	http://eprints.uni-mysore.ac.in/id/eprint/5936

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