Schiffs bases derived from amino acids-imidazole conjugates as promising antioxidant and antimicrobial agents

Ullas, B. J. and Avinash, P. and Rakesh, K. P. and Chandrashekar, P. G. and Channe Gowda, D. and Suhas, R. (2015) Schiffs bases derived from amino acids-imidazole conjugates as promising antioxidant and antimicrobial agents. Journal of Chemistry and Applied Biochemistry, 2 (1). ISSN 2394-3106

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Abstract

A series of amino acids conjugated imidazole derivatives were synthesized and characterized by standard spectroscopical techniques. The title compoundswere evaluated for their in vitro antimicrobial activity against bacteria and fungi by zone of inhibition method. The results showed that this skeletal frameworkexhibited interesting potency as antimicrobial agents. Amongst, compounds 10,11,13,14,16,17 and 18 showed most potent gram negative and gram positiveantibacterial activity whereas compounds 11,12,14,15,17 and 26 displayed most potent antifungal activity against A. niger and compounds 16,17,18, 21,22and 24 exhibited good antifungal activity against F. oxysporum species. On the other hand, conjugates 11,12,13,14,15,16,17 and 18 showed very goodantioxidant activity compared to commercial standard drugs. The results highlight the amino acids conjugated imidazole derivatives as potential leads fordesigning new future antimicrobial drug candidates possessing good antioxidant properties.

Item Type: Article
Uncontrolled Keywords: Imidazole and Amino Acids and Conjugation and Antimicrobial Activity
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 25 Jul 2019 06:41
Last Modified: 25 Jul 2019 06:41
URI: http://eprints.uni-mysore.ac.in/id/eprint/5550

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