Harsha, K. B. and Swaroop, T. R. and Roopashree, Rangaswamy and Jagadish, Swamy and Rangappa, K. S. (2018) Synthesis and in vitro anti-proliferative studies of new 2-(arylmethylthio)-6-ethyl-7H-pyrrolo2,3-dpyrimidin-4-ols. Chemical Data Collections, 15-16. 223 - 228.
Full text not available from this repository. (Request a copy)Abstract
Synthesis of a series of 2-(arylmethylthio)-6-ethyl-7H-pyrrolo2,3-dpyrimidin-4-ol and their cytotoxic activity on HCT-116 and A-549 cell lines using MTT assay is reported. The 6-ethyl-2-((4-fluorobenzyl)thio)-7H-pyrrolo2,3-dpyrimidin-4-ol 3d is the most active compound on HCT-116 with IC50 of 8.65 ± 0.36 µM. On the other hand, 6-ethyl-2-((3-nitrobenzyl)thio)-7H-pyrrolo2,3-dpyrimidin-4-ol 3i and 2-((2-bromo‑3,4-dimethoxybenzyl)thio)-6-ethyl-7H-pyrrolo2,3-dpyrimidin-4-ol 3j exhibited high activities on A-549 with IC50 values 2.7 ± 0.49 µM and 2.21 ± 0.66 µM respectively.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 25 Jul 2019 06:00 |
| Last Modified: | 25 Jul 2019 06:00 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/5541 |
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