Regioselective synthesis of n-formohydrazide and formyl pyrazole analogs as potent antimicrobial agents

Raghavendra, K. R. and Girish, Y. R. and Ajay Kumar, K. and Shashikanth, S. (2015) Regioselective synthesis of n-formohydrazide and formyl pyrazole analogs as potent antimicrobial agents. Journal of Chemical and Pharmaceutical Research, 7 (6). pp. 361-366. ISSN 0975-7384

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Abstract

A series of new (E)-N-(aryl)-N'-(1-(thiophen-2-yl)ethylidene)formohydrazides 2(a-g) and 1-(aryl)-3-(thiophen-2-yl)- 1H-pyrazole-4-carbaldehyde, 3(a-g) were prepared by the controlled Vilsmeier-Haack reaction. The reaction of (E)-1-aryl-2-(1-thiophen-2-yl)ethylidenehydrazines 1(a-g) with Vilsmeier-Haack reagent under different reaction conditions afforded the compounds 2(a-g) and 3(a-g) in good yield. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR, Mass spectral, x-ray diffraction studies and elemental analysis. The compounds were screened for their antimicrobial susceptibility against different bacterium and fungi species

Item Type: Article
Uncontrolled Keywords: Antibacterial and Antifungal and Formyl Pyrazoles and Hydrazines and Inhibition
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Yuvaraj college > Chemistry
Depositing User: Shrirekha N
Date Deposited: 25 Jul 2019 06:00
Last Modified: 25 Jul 2019 06:00
URI: http://eprints.uni-mysore.ac.in/id/eprint/5540

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