Synthesis and antifungal activity of novel pyrimidin-2-one analogues

Shwetha Hegde, G. and Dileep Kumar, A. and Ajay Kumar, K. (2015) Synthesis and antifungal activity of novel pyrimidin-2-one analogues. Journal of Chemical and Pharmaceutical Research, 7 (8). pp. 72-76. ISSN 0975-7384

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A series of thiophene appended substituted pyrimidin-2-one analogues were synthesized by an accessible approach. The reaction of chalcones 1(a-e) and urea 2 in the presence potassium hydroxide in ethanol yielded 6-aryl-4- (thiophen-2-yl)-5,6-dihydropyrimidin-2(1H)-ones, 3(a-e) in good yields. The synthesized new compounds were characterized by 1H NMR, 13C NMR, Mass spectral studies and elemental analysis and were screened for their antifungal susceptibility against different fungi species

Item Type: Article
Uncontrolled Keywords: Antifungal and Cyclocondensation and Inhibition and Pyrimidine and Urea
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Shrirekha N
Date Deposited: 24 Jul 2019 09:37
Last Modified: 24 Jul 2019 09:37

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