An easy route to synthesis of thiophene tagged pyrimidin-2-thiones as antibacterial agents

Shruthi, V. K. and Vagish, C. B. and Ajay Kumar, K. (2015) An easy route to synthesis of thiophene tagged pyrimidin-2-thiones as antibacterial agents. Journal of Chemical and Pharmaceutical Research, 7 (8). pp. 39-43. ISSN 0975-7384

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Abstract

A series of substituted pyrimidin-2-thiones tagged with thiophene moiety was synthesized by an easy procedure. The reaction of chalcones 1-5 and thiourea 6 in the presence potassium hydroxide in ethanol yielded 6-aryl-4-(thiophen- 2-yl) -5,6-dihydropyrimidin-2(1H) -ones, 7-11 in good yields. The synthesized new compounds were characterized by 1H NMR, 13C NMR, Mass spectral studies and elemental analysis and were screened for their antifungal susceptibility against different bacteria species

Item Type: Article
Uncontrolled Keywords: Antibacterial and Cyclocondensation and Inhibition and Pyrimidine and Thiourea
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Shrirekha N
Date Deposited: 24 Jul 2019 09:32
Last Modified: 24 Jul 2019 09:32
URI: http://eprints.uni-mysore.ac.in/id/eprint/5523

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