Synthesis, characterization, anti-angiogenic and anti-oxidant activities of 1,5-benzothiazepin-4-(5h)-one derivatives

Deepu, C. V. and Rekha, N. D. and Raghavendra, G. M. and Bhadregowda, D. G. (2015) Synthesis, characterization, anti-angiogenic and anti-oxidant activities of 1,5-benzothiazepin-4-(5h)-one derivatives. Journal of Chemical and Pharmaceutical Research, 7 (12). pp. 733-740. ISSN 0975-7384

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Abstract

New 1,5-benzothiazepin-4-(5H)-one derivatives (9a-9e) have been synthesized. The anti-angiogenic and antioxidant properties of the new derivatives were then evaluated. All the compounds (9a-9e) exhibited very good inhibition of capillary proliferation, thus proving their anti-angiogenic properties. In addition, the in vitro antioxidant activities of these compounds were evaluated using diphenyl picryl hydrazine (DPPH), and NO (nitric oxide) assays, and the results were compared with butylated hydroxytoluene (BHT), a well known anti-oxidant. Compounds (9a-9e) showed excellent free-radical scavenging activities in the nitric oxide assay, thus proving to be more potent than BHT.

Item Type: Article
Uncontrolled Keywords: 1 and 5-Benzothiazepin-4-(5H)-One and Anti-Angiogenic and Anti-Oxidants and Suzuki Coupling
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Shrirekha N
Date Deposited: 24 Jul 2019 06:05
Last Modified: 19 Dec 2019 09:21
URI: http://eprints.uni-mysore.ac.in/id/eprint/5505

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