An efficient route to synthesis of pyrazoline carboxamides bearing thiophene moiety as antimicrobial agents

Vijaychand, S. P. and Pavithra, G. and Raghavendra, K. R. and Ajay, K. (2015) An efficient route to synthesis of pyrazoline carboxamides bearing thiophene moiety as antimicrobial agents. Der Pharma Chemica, 7 (4). pp. 85-89. ISSN 0975-413X

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Abstract

A series of new pyrazoline carbothioamides bearing thiophene moiety were synthesized by simple one pot procedure. The cyclocondensation reaction of chalcones 1a-g and semicarbazine 2 in the presence potassium hydroxide in ethanol yielded 5-(4-aryl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboxamides 3a-g in excellent yield. The synthesized new products were characterized by 1H NMR, 13C NMR, Mass spectral studies and elemental analysis. The compounds were tested for their antimicrobial susceptibility against different bacterium and fungi species.

Item Type: Article
Uncontrolled Keywords: Antibacterial and Antifungal and Carboxamide and Cyclocondensation and Inhibition
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Shrirekha N
Date Deposited: 23 Jul 2019 07:25
Last Modified: 23 Jul 2019 07:25
URI: http://eprints.uni-mysore.ac.in/id/eprint/5473

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