Synthesis of New Lignan libraries; studies on their antimicrobial inhibition effect

Raghavendra, K. R. and Shashikanth, S. and Ajay, K. (2015) Synthesis of New Lignan libraries; studies on their antimicrobial inhibition effect. Der Pharma Chemica, 7 (7). pp. 153-160.

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Abstract

A series of new lignan analogues were synthesized by simple and accessible procedure. The cyclocondensation reaction of 3-(ethoxycarbonyl)-4,4-(diaryl)but-3-enoic acids, 1(a-e) with acetic anhydride in glacial acetic acid produced Ethyl 4-acetoxy-6-ethoxy-1-(4-aryl)-2-naphthoates 2(a-e) and with polyphosphosphoric acid yielded Ethyl 1-aryl-6-ethoxy-4-hydroxy-2-naphthoates 4(a-e) in good yields. The new compounds were characterized by spectral and elemental analysis and were tested for their antimicrobial inhibitory effect against different bacterium and fungi species.

Item Type: Article
Uncontrolled Keywords: Acetic Anhydride and Antibacterial and Antifungal and Cyclocondensation and Inhibition and PPA
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 23 Jul 2019 07:01
Last Modified: 23 Jul 2019 07:01
URI: http://eprints.uni-mysore.ac.in/id/eprint/5469

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